Critical Reviews in Oncology / Hematology
Volume 79, Issue 2 , Pages 196-204 , August 2011

Adjuvant chemotherapy in elderly patients with early breast cancer. Impact of age and comprehensive geriatric assessment on tumor board proposals

  • P. Barthélémy

      Affiliations

    • Pôle d’Hématologie et d’Oncologie, Hôpitaux Universitaires de Strasbourg, France
    • ,
  • D. Heitz

      Affiliations

    • Unité Pilote d’Oncogériatrie, Hôpitaux Universitaires de Strasbourg and Centre Paul Strauss, Strasbourg, France
    • ,
  • C. Mathelin

      Affiliations

    • Pôle de Gynécologie – Obstétrique, Hôpitaux Universitaires de Strasbourg, France
    • ,
  • H. Polesi

      Affiliations

    • Observatoire Régional de la Santé d’Alsace, Strasbourg, France
    • ,
  • I. Asmane

      Affiliations

    • Pôle d’Hématologie et d’Oncologie, Hôpitaux Universitaires de Strasbourg, France
    • ,
  • V. Litique

      Affiliations

    • Pôle d’Hématologie et d’Oncologie, Hôpitaux Universitaires de Strasbourg, France
    • ,
  • L. Rob

      Affiliations

    • Pôle d’Hématologie et d’Oncologie, Hôpitaux Universitaires de Strasbourg, France
    • ,
  • J.-P. Bergerat

      Affiliations

    • Pôle d’Hématologie et d’Oncologie, Hôpitaux Universitaires de Strasbourg, France
    • ,
  • J.-E. Kurtz

      Affiliations

    • Pôle d’Hématologie et d’Oncologie, Hôpitaux Universitaires de Strasbourg, France
    • Unité Pilote d’Oncogériatrie, Hôpitaux Universitaires de Strasbourg and Centre Paul Strauss, Strasbourg, France
    • Corresponding Author InformationCorresponding author at: Pôle d’Hématologie et d’Oncologie, Hôpitaux Universitaires de Strasbourg, France. Tel.: +33 3 88 12 84 36; fax: +33 3 88 12 76 81.

,Accepted 25 June 2010.

References 

  1. Yancik R, Ries LA. Aging and cancer in America. Demographic and epidemiologic perspectives. Hematol Oncol Clin North Am. 2000;14(1):17–23
  2. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58(2):71–96
  3. Brunello A, Basso U, Pogliani C, Jirillo A, Ghiotto C, Koussis H, et al. Adjuvant chemotherapy for elderly patients (> or =70 years) with early high-risk breast cancer: a retrospective analysis of 260 patients. Ann Oncol. 2005;16(8):1276–1282
  4. Giordano SH, Duan Z, Kuo YF, Hortobagyi GN, Goodwin JS. Use and outcomes of adjuvant chemotherapy in older women with breast cancer. J Clin Oncol. 2006;24(18):2750–2756
  5. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005;365(9472):1687–717.
  6. Muss HB, Berry DA, Cirrincione CT, Theodoulou M, Mauer AM, Kornblith AB, et al. Adjuvant chemotherapy in older women with early-stage breast cancer. N Engl J Med. 2009;360(20):2055–2065
  7. DeMichele A, Putt M, Zhang Y, Glick JH, Norman S. Older age predicts a decline in adjuvant chemotherapy recommendations for patients with breast carcinoma: evidence from a tertiary care cohort of chemotherapy-eligible patients. Cancer. 2003;97(9):2150–2159
  8. Giordano SH, Hortobagyi GN, Kau SW, Theriault RL, Bondy ML. Breast cancer treatment guidelines in older women. J Clin Oncol. 2005;23(4):783–791
  9. Balducci L, Beghe C. The application of the principles of geriatrics to the management of the older person with cancer. Crit Rev Oncol Hematol. 2000;35(3):147–154
  10. Extermann M, Aapro M, Bernabei R, Cohen HJ, Droz JP, Lichtman S, et al. Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG). Crit Rev Oncol Hematol. 2005;55(3):241–252
  11. Extermann M, Meyer J, McGinnis M, Crocker TT, Corcoran MB, Yoder J, et al. A comprehensive geriatric intervention detects multiple problems in older breast cancer patients. Crit Rev Oncol Hematol. 2004;49(1):69–75
  12. Hebert-Croteau N, Brisson J, Latreille J, Rivard M, Abdelaziz N, Martin G. Compliance with consensus recommendations for systemic therapy is associated with improved survival of women with node-negative breast cancer. J Clin Oncol. 2004;22(18):3685–3693
  13. McPherson CP, Swenson KK, Lee MW. The effects of mammographic detection and comorbidity on the survival of older women with breast cancer. J Am Geriatr Soc. 2002;50(6):1061–1068
  14. Litvak DA, Arora R. Treatment of elderly breast cancer patients in a community hospital setting. Arch Surg. 2006;141(10):985–990[discussion 990]
  15. Kurtz JE, Heitz D, Enderlin P, Imbert F, Nehme H, Bergerat JP, et al. Geriatric oncology, general practitioners and specialists: current opinions and unmet needs. Crit Rev Oncol Hematol. 2009;

PII: S1040-8428(10)00148-4

doi: 10.1016/j.critrevonc.2010.06.005

Critical Reviews in Oncology / Hematology
Volume 79, Issue 2 , Pages 196-204 , August 2011

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