Critical Reviews in Oncology / Hematology
Volume 79, Issue 1 , Pages 1-16, July 2011

MUTYH-associated polyposis (MAP)

  • Maartje Nielsen

      Affiliations

    • Department Clinical Genetics, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    • Corresponding Author InformationCorresponding author. Fax: +31 71 5266749.
    • ,
  • Hans Morreau

      Affiliations

    • Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    • ,
  • Hans F.A. Vasen

      Affiliations

    • Dutch Hereditary Cancer Registry and Department of Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands
    • ,
  • Frederik J. Hes

      Affiliations

    • Department Clinical Genetics, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands

Accepted 27 May 2010. published online 22 July 2010.

Abstract 

The human mutY homologue (MUTYH) gene is responsible for inheritable polyposis and colorectal cancer. This review discusses the molecular genetic aspects of the MUTYH gene and protein, the clinical impact of mono- and biallelic MUTYH mutations and histological aspects of the MUTYH tumors. Furthermore, the relationship between MUTYH and the mismatch repair genes in colorectal cancer (CRC) families is examined. Finally, the role of other base excision repair genes in polyposis and CRC patients is discussed.

Keywords: MUTYH-associated polyposis, MUTYH gene, MAP, Colorectal cancer, Polyposis

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PII: S1040-8428(10)00147-2

doi:10.1016/j.critrevonc.2010.05.011

Critical Reviews in Oncology / Hematology
Volume 79, Issue 1 , Pages 1-16, July 2011

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