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Volume 74, Issue 2, Pages 106-133 (May 2010)


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Colon cancer

Roberto LabiancaaCorresponding Author Informationemail address, Giordano D. Berettab, Basem Kildanib, Laura Milesia, Federica Merlinb, Stefania Mosconia, M. Adelaide Pessia, Tiziana Prochilob, Antonello Quadria, Gemma Gattac, Filippo de Braudd, Jacques Wilse

Accepted 6 January 2010. published online 08 February 2010.

Abstract 

Colon cancer is one of the leading tumours in the world and it is considered among the big killers, together with lung, prostate and breast cancer. In the recent years very important advances occurred in the field of treatment of this frequent disease: adjuvant chemotherapy was demonstrated to be effective, chiefly in stage III patients, and surgery was optimized in order to achieve the best results with a low morbidity. Several new target-oriented drugs are under evaluation and some of them (cetuximab and bevacizumab) have already exhibited a good activity/efficacy, mainly in combination with chemotherapy. The development of updated recommendations for the best management of these patients is crucial in order to obtain the best results, not only in clinical research but also in every-day practice. This report summarizes the most important achievements in this field and provides the readers useful suggestions for their professional practice.

a Ospedali Riuniti, Largo Barozzi 1, 24128 Bergamo, Italy

b Ospedale Sant’Orsola Fatebenefratelli, Brescia, Italy

c Fondazione IRCCS “Istituto Nazionale dei Tumori”, Milan, Italy

d START Project and European Institute of Oncology, Milan, Italy

e Laurentius Hospital, Roermond, The Netherlands

Corresponding Author InformationCorresponding author. Tel.: +39 035 269860.

PII: S1040-8428(10)00011-9

doi:10.1016/j.critrevonc.2010.01.010


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