Critical Reviews in Oncology / Hematology
Volume 77, Issue 1 , Pages 63-69 , January 2011

A mini geriatric assessment helps treatment decision in elderly patients with digestive cancer. A pilot study

  • Thomas Aparicio

      Affiliations

    • Service d’Hépato-Gastroentérologie, Hôpital Bichat-Claude Bernard, APHP, 46 rue Henri Huchard, 75018 Paris, France
    • Service de Gastroentérologie, Hôpital Avicenne, APHP, 125 rue de Stalingrad, 93000 Bobigny, France
    • Corresponding Author InformationCorresponding author at: Service de Gastroentérologie, Hôpital Avicenne, APHP, 125 rue de Stalingrad, 93000 Bobigny, France. Tel.: +33 1 48 95 54 34; fax: +33 1 48 95 54 39.
    • ,
  • Laurence Girard

      Affiliations

    • Service de Gériatrie, Hôpital Bichat-Claude Bernard, APHP, 46 rue Henri Huchard, 75018 Paris, France
    • ,
  • Nadia Bouarioua

      Affiliations

    • Service d’Hépato-Gastroentérologie, Hôpital Bichat-Claude Bernard, APHP, 46 rue Henri Huchard, 75018 Paris, France
    • ,
  • Claire Patry

      Affiliations

    • Service de Gériatrie, Hôpital Bichat-Claude Bernard, APHP, 46 rue Henri Huchard, 75018 Paris, France
    • ,
  • Sylvie Legrain

      Affiliations

    • Service de Gériatrie, Hôpital Bichat-Claude Bernard, APHP, 46 rue Henri Huchard, 75018 Paris, France
    • ,
  • Jean Claude Soulé

      Affiliations

    • Service d’Hépato-Gastroentérologie, Hôpital Bichat-Claude Bernard, APHP, 46 rue Henri Huchard, 75018 Paris, France

,Accepted 6 January 2010.

References 

  1. Vercelli M, Capocaccia R, Quaglia A, Casella C, Puppo A, Coebergh JW. Relative survival in elderly European cancer patients: evidence for health care inequalities. The EUROCARE Working Group. Crit Rev Oncol Hematol. 2000;35:161–179
  2. Yee KW, Pater JL, Pho L, Zee B, Siu LL. Enrollment of older patients in cancer treatment trials in Canada: why is age a barrier?. J Clin Oncol. 2003;21:1618–1623
  3. Aparicio T, Desrame J, Lecomte T, et al. Oxaliplatin- or irinotecan-based chemotherapy for metastatic colorectal cancer in the elderly. Br J Cancer. 2003;89:1439–1444
  4. Folprecht G, Cunningham D, Ross P, et al. Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer: a pooled analysis of clinical trials. Ann Oncol. 2004;15:1330–1338
  5. Sargent DJ, Goldberg RM, Jacobson SD, et al. A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med. 2001;345:1091–1097
  6. Tabah-Fisch I, Maindrault-Goebel F, Benavides M, Zaniboni A, Bigelow R, Bleiberg H. Oxaliplatin/5 FU/LV is feasible, safe and active in elderly colorectal cancer patients. Proc Am Soc Clin Oncol. 2002;21:140a
  7. Fong Y, Blumgart LH, Fortner JG, Brennan MF. Pancreatic or liver resection for malignancy is safe and effective for the elderly. Ann Surg. 1995;222:426–434
  8. Turrini O, Guiramand J, Moutardier V, et al. Major hepatectomy for metastasis of colorectal cancer improves survival in the elderly. Ann Chir. 2005;130:562–565
  9. Brozzetti S, Mazzoni G, Miccini M, et al. Surgical treatment of pancreatic head carcinoma in elderly patients. Arch Surg. 2006;141:137–142
  10. Minagawa M, Makuuchi M, Torzilli G, et al. Extension of the frontiers of surgical indications in the treatment of liver metastases from colorectal cancer: long-term results. Ann Surg. 2000;231:487–499
  11. Aparicio T, Navazesh A, Boutron I, et al. Half of elderly patients routinely treated for colorectal cancer receive a sub-standard treatment. Crit Rev Oncol Hematol. 2009;
  12. Bouvier AM, Launoy G, Lepage C, Faivre J. Trends in the management and survival of digestive tract cancers among patients aged over 80 years. Aliment Pharmacol Ther. 2005;22:233–241
  13. Mahoney T, Kuo YH, Topilow A, Davis JM. Stage III colon cancers: why adjuvant chemotherapy is not offered to elderly patients. Arch Surg. 2000;135:182–185
  14. Aparicio T, Mitry E, Sa Cunha A, Girard L. Management of colorectal cancer of elderly patients. Gastroenterol Clin Biol. 2005;29:1014–1023
  15. Cohen HJ, Feussner JR, Weinberger M, et al. A controlled trial of inpatient and outpatient geriatric evaluation and management. N Engl J Med. 2002;346:905–912
  16. Stuck AE, Siu AL, Wieland GD, Adams J, Rubenstein LZ. Comprehensive geriatric assessment: a meta-analysis of controlled trials. Lancet. 1993;342:1032–1036
  17. Tinetti ME, Baker DI, McAvay G, et al. A multifactorial intervention to reduce the risk of falling among elderly people living in the community. N Engl J Med. 1994;331:821–827
  18. Hurria A, Gupta S, Zauderer M, et al. Developing a cancer-specific geriatric assessment: a feasibility study. Cancer. 2005;104:1998–2005
  19. Mohile SG, Bylow K, Dale W, et al. A pilot study of the vulnerable elders survey-13 compared with the comprehensive geriatric assessment for identifying disability in older patients with prostate cancer who receive androgen ablation. Cancer. 2007;109:802–810
  20. Overcash JA, Beckstead J, Moody L, Extermann M, Cobb S. The abbreviated comprehensive geriatric assessment (aCGA) for use in the older cancer patient as a prescreen: scoring and interpretation. Crit Rev Oncol Hematol. 2006;59:205–210
  21. Balducci L, Extermann M. Management of cancer in the older person: a practical approach. Oncologist. 2000;5:224–237
  22. Linn BS, Linn MW, Gurel L. Cumulative illness rating scale. J Am Geriatr Soc. 1968;16:622–626
  23. Katz D, Ford A, Moskowitz R. Studies of illness in the aged. The index ADL: a standardized measure of biological and psychological function. JAMA. 1963;186:914–919
  24. Lawton M, Brody E. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9:179–186
  25. Cockrell JR, Folstein MF. Mini-mental state examination (MMSE). Psychopharmacol Bull. 1988;24:689–692
  26. Guigoz Y, Vellas B. The Mini Nutritional Assessment (MNA) for grading the nutritional state of elderly patients: presentation of the MNA, history and validation. Nestle Nutr Workshop Ser Clin Perform Programme. 1999;1:3–11
  27. Clement JP, Nassif RF, Leger JM, Marchan F. Development and contribution to the validation of a brief French version of the Yesavage Geriatric Depression Scale. Encephale. 1997;23:91–99
  28. McCorkle R, Strumpf NE, Nuamah IF, et al. A specialized home care intervention improves survival among older post-surgical cancer patients. J Am Geriatr Soc. 2000;48:1707–1713
  29. Freyer G, Geay JF, Touzet S, et al. Comprehensive geriatric assessment predicts tolerance to chemotherapy and survival in elderly patients with advanced ovarian carcinoma: a GINECO study. Ann Oncol. 2005;16:1795–1800
  30. Maas HA, Janssen-Heijnen ML, Olde Rikkert MG, Machteld Wymenga AN. Comprehensive geriatric assessment and its clinical impact in oncology. Eur J Cancer. 2007;43:2161–2169
  31. Fonck M, Blanc-Bisson C, Mathoulin-Pelissier S, et al. Screening des patients âgés diagnostiqués pour un cancer et à risque de décès précoce. Résultats d’une étude prospective multicentrique de 364 patients traités par chimiothérapie. Gastroenterol Clin Biol. 2007;31:[HS II] Ref Type: Abstract
  32. Girre V, Falcou MC, Gisselbrecht M, et al. Does a geriatric oncology consultation modify the cancer treatment plan for elderly patients?. J Gerontol A: Biol Sci Med Sci. 2008;63:724–730
  33. Extermann M, Meyer J, McGinnis M, et al. A comprehensive geriatric intervention detects multiple problems in older breast cancer patients. Crit Rev Oncol Hematol. 2004;49:69–75
  34. Mitry E, Phelip JM, Bonnetain F, et al. Phase III trial of chemotherapy with or without irinotecan in the front-line treatment of metastatic colorectal cancer in elderly patients (FFCD 2001-02 trial): results of a planned interim analysis. In: Proceedings of ASCO GI Cancer Symposium, A281. 2008;Ref Type: Abstract
  35. Retornaz F, Monette J, Batist G, et al. Usefulness of frailty markers in the assessment of the health and functional status of older cancer patients referred for chemotherapy: a pilot study. J Gerontol A: Biol Sci Med Sci. 2008;63:518–522
  36. Extermann M, Aapro M, Bernabei R, et al. Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG). Crit Rev Oncol Hematol. 2005;55:241–252

PII: S1040-8428(10)00004-1

doi: 10.1016/j.critrevonc.2010.01.003

Critical Reviews in Oncology / Hematology
Volume 77, Issue 1 , Pages 63-69 , January 2011

Article Tools

* Image Usage & Resolution