Critical Reviews in Oncology / Hematology
Volume 75, Issue 2 , Pages 138-150 , August 2010

Prescribers’ attitudes toward elderly breast cancer patients. Discrimination or empathy?

  • Christel Protière

      Affiliations

    • INSERM, U-912 “Economic & Social Sciences, Health Systems & Societies” (SE4S), Marseille, F-13273, France
    • Université Aix Marseille, IRD, Marseille, F-13007, France
    • Corresponding Author InformationCorresponding author at: INSERM, UMR 912 “Economic & Social Sciences, Health Systems & Societies” (SE4S), 23, rue Stanislas Torrents, ORS PACA, 13006 Marseille, France. Tel.: +33 4 91 59 89 16; fax: +33 4 91 59 89 24.
  • ,
  • Patrice Viens

      Affiliations

    • Université Aix Marseille, Faculté de Médecine, Marseille, F-13007, France
    • Institut Paoli-Calmettes, Marseille, F-13273, France
  • ,
  • Frédérique Rousseau

      Affiliations

    • Institut Paoli-Calmettes, Marseille, F-13273, France
  • ,
  • Jean Paul Moatti

      Affiliations

    • INSERM, U-912 “Economic & Social Sciences, Health Systems & Societies” (SE4S), Marseille, F-13273, France
    • Université Aix Marseille, IRD, Marseille, F-13007, France

,Accepted 24 September 2009.

References 

  1. Gajdos C, Tartter PI, Bleiweiss IJ, Lopchinsky RA, Bernstein JL. The consequence of undertreating breast cancer in the elderly. Journal of the American College of Surgeons. 2001;192(6):698–707
  2. Firvida JL, Vinolas N, Munoz M, et al. Age: a critical factor in cancer management. A prospective comparative study of 400 patients. Age and Ageing. 1999;28(2):103–105
  3. Monfardini S. Opening lecture. In: 3rd SIOG meeting. 7th international conference on geriatric oncology—cancer in the elderly. Boston. 2002;
  4. Townsley C, Pond GR, Peloza B, et al. Analysis of treatment practices for elderly cancer patients in Ontario, Canada. Journal of Clinical Oncology. 2005;23(16):3802–3810
  5. Perkins P, Cooksley CD, Singletary SE, Cox JD. Differences in breast cancer treatment and survival between older and younger women. The Breast Journal. 1999;5(3):156–161
  6. Hurria A, Naeim A, Elkin E, et al. Adjuvant treatment recommendations in older women with breast cancer—a survey of oncologists. Critical Reviews in Oncology/Hematology. 2006;
  7. Evans JG. Introduction. In:  Evans W,  Miche Beattie, Wilcock  editor. Oxford textbook of geriatric medicine. 2nd ed.. Oxford University Press; 2000;
  8. Balducci L, Extermann M, Carreca I. Management of breast cancer in the older woman. Cancer Control. 2001;8(5):431–441
  9. Truong PT, Bernstein V, Wai E, Chua B, Speers C, Olivotto IA. Age-related variations in the use of axillary dissection: a survival analysis of 8038 women with T1-ST2 breast cancer. International Journal of Radiation Oncology Biology Physics. 2002;54(3):794–803
  10. Aapro MS. The frail are not always elderly. Journal of Clinical Oncology. 2005;23(10):2121–2122
  11. Velanovich V, Gabel M, Walker EM, et al. Causes for the undertreatment of elderly breast cancer patients: tailoring treatments to individual patients. Journal of the American College of Surgeons. 2002;194(1):8–13
  12. Yancik R, Ganz PA, Varricchio CG, Conley B. Perspectives on comorbidity and cancer in older patients: approaches to expand the knowledge base. Journal of Clinical Oncology. 2001;19(4):1147–1151
  13. Castiglione M, Gelber RD, Goldhirsch A International Breast Cancer Study Group. Adjuvant systemic therapy for breast cancer in the elderly: competing causes of mortality. Journal of Clinical Oncology. 1990;8(3):519–526
  14. Cummings FJ, Gray RE, Tormey DC, et al. Adjuvant tamoxifen versus placebo in elderly women with node-positive breast cancer: long-term follow-up and causes of death. Journal of Clinical Oncology. 1993;11(1):29–35
  15. Guadagnoli E, Shapiro C, Gurwitz JH, et al. Age-related patterns of care: evidence against ageism in the treatment of early-stage breast cancer. Journal of Clinical Oncology. 1997;15(6):2338–2344
  16. Bouchardy C, Rapiti E, Fioretta G, et al. Undertreatment strongly decreases prognosis of breast cancer in elderly women. Journal of Clinical Oncology. 2003;21(19):3580–3587
  17. Popescu RA, Norman A, Ross PJ, Parikh B, Cunningham D. Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older. Journal of Clinical Oncology. 1999;17(8):2412–2418
  18. Crivellari D, Aapro M, Leonard R, et al. Breast cancer in the elderly. Journal of Clinical Oncology. 2007;25(14):1882–1890
  19. Crivellari D, Bonetti M, Castiglione-Gertsch M, et al. Burdens and benefits of adjuvant cyclophosphamide, methotrexate, and fluorouracil and tamoxifen for elderly patients with breast cancer: the international breast cancer study group trial VII. Journal of Clinical Oncology. 2000;18(7):1412–1422
  20. Pritchard KI, Paterson AH, Fine S, et al. Randomized trial of cyclophosphamide, methotrexate, and fluorouracil chemotherapy added to tamoxifen as adjuvant therapy in postmenopausal women with node-positive estrogen and/or progesterone receptor-positive breast cancer: a report of the National Cancer Institute of Canada Clinical Trials Group. Journal of Clinical Oncology. 1997;15(6):2302–2311
  21. Yood MU, Owusu C, Buist DS, et al. Mortality impact of less-than-standard therapy in older breast cancer patients. Journal of the American College of Surgeons. 2008;206(1):66–75
  22. Enger SM, Thwin SS, Buist DS, et al. Breast cancer treatment of older women in integrated health care settings. Journal of Clinical Oncology. 2006;24(27):4377–4383
  23. Hershman DL, Buono D, McBride RB, et al. Surgeon characteristics and receipt of adjuvant radiotherapy in women with breast cancer. Journal of the National Cancer Institute. 2008;100(3):199–206
  24. Silliman RA, Demissie S, Troyan SL. The care of older women with early-stage breast cancer: what is the role of surgeon gender?. Medical Care. 1999;37(10):1057–1067
  25. Mandelblatt JS, Berg CD, Meropol NJ, et al. Measuring and predicting surgeons’ practice styles for breast cancer treatment in older women. Medical Care. 2001;39(3):228–242
  26. Ellis RP, McGuire TG. Hospital response to prospective payment: moral hazard, selection, and practice-style effects. Journal of Health Economics. 1996;15(3):257–277
  27. Balducci L, Extermann M. Management of cancer in the older person: a practical approach. Oncologist. 2000;5(3):224–237
  28. Chen H, Cantor A, Meyer J, et al. Can older cancer patients tolerate chemotherapy? A prospective pilot study. Cancer. 2003;97(4):1107–1114
  29. Extermann M, Overcash J, Lyman GH, Parr J, Balducci L. Comorbidity and functional status are independent in older cancer patients. Journal of Clinical Oncology. 1998;16(4):1582–1587
  30. Kohne CH, Folprecht G, Goldberg RM, Mitry E, Rougier P. Chemotherapy in elderly patients with colorectal cancer. Oncologist. 2008;13(4):390–402
  31. Jones TV, Gerrity MS, Earp J. Written case simulations: do they predict physicians’ behavior?. Journal of Clinical Epidemiology. 1990;43(8):805–815
  32. Protiere C, Moumjid N, Le Corroller Soriano AG, Malavolti L, Moatti JP. Patients’ information seeking behavior in cancer: is there more than a communication problem with the medical team?. Oslo, Norway: EACH; 2008;
  33. Du XL, Key CR, Osborne C, Mahnken JD, Goodwin JS. Discrepancy between consensus recommendations and actual community use of adjuvant chemotherapy in women with breast cancer. Annals of Internal Medicine. 2003;138(2):90–97
  34. Fisher B, Redmond C, Legault-Poisson S, et al. Postoperative chemotherapy and tamoxifen compared with tamoxifen alone in the treatment of positive-node breast cancer patients aged 50 years and older with tumors responsive to tamoxifen: results from the National Surgical Adjuvant Breast and Bowel Project B-16. Journal of Clinical Oncology. 1990;8(6):1005–1018
  35. Luchini S, Protière C, Moatti JP. Evaluating several willingness to pay in a single contingent evaluation: application to health care. Health Economics. 2003;12(1):51–64
  36. Protière C, Donaldson C, Moatti JP, Luchini S, Shackley P. The impact of information on non-health attributes on willingness to pay for multiple health care programmes. Social Science & Medicine. 2004;58(7):1257–1269
  37. Bailey C, Corner J, Addington-Hall J, Kumar D, Nelson M, Haviland J. Treatment decisions in older patients with colorectal cancer: the role of age and multidimensional function. European Journal of Cancer Care. 2003;12(3):257–262
  38. Bernardi D, Errante D, Galligioni E, et al. Treatment of breast cancer in older women. Acta Oncology. 2007;1–13
  39. Gosney M. Contribution of the geriatrician to the management of cancer in older patients. European Journal of Cancer. 2007;43(15):2153–2160
  40. Maas HA, Janssen-Heijnen ML, Olde Rikkert MG, Machteld Wymenga AN. Comprehensive geriatric assessment and its clinical impact in oncology. European Journal of Cancer. 2007;43(15):2161–2169
  41. Mandelblatt JS, Edge SB, Meropol NJ, et al. Predictors of long-term outcomes in older breast cancer survivors: perceptions versus patterns of care. Journal of Clinical Oncology. 2003;21(5):855–863
  42. Elkin EB, Kim SHM, Casper ES, Kissane DW, Schrag D. Desire for information and involvement in treatment decisions: elderly cancer patients’ preferences and their physicians’ perceptions. Journal of Clinical Oncology. 2007;25(33):5275–5280

PII: S1040-8428(09)00197-8

doi: 10.1016/j.critrevonc.2009.09.007

Critical Reviews in Oncology / Hematology
Volume 75, Issue 2 , Pages 138-150 , August 2010