« Previous
Next »
Critical Reviews in Oncology / Hematology
Volume 74, Issue 3
, Pages 163-174
, June 2010
Review role of topotecan in gynaecological cancers: Current indications and perspectives
References
- Cancer statistics, 2004. CA Cancer J Clin. 2004;54:8–29
- . Cancer incidence and mortality in Europe, 2004. Ann Oncol. 2005;16:481–488
- . ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of epithelial ovarian carcinoma. Ann Oncol. 2005;16(Suppl. 1):i13–i15
- . Workshop: options for therapy in ovarian cancer. Gynecol Oncol. 2003;90:S45–50
- Clinical practice guidelines 2008 for the surgical treatment, medical first-line and consolidation treatments of patients with epithelial ovarian cancer—update. According to the methodology of Standards, Options: Recommendations (SOR). Bull Cancer. 2008;95:881–886
- Topotecan for the treatment of advanced epithelial ovarian cancer: an open-label phase II study in patients treated after prior chemotherapy that contained cisplatin or carboplatin and paclitaxel. J Clin Oncol. 1998;16:3345–3352
- Topotecan, an active drug in the second-line treatment of epithelial ovarian cancer: results of a large European phase II study. J Clin Oncol. 1996;14:3056–3061
- . Management of recurrent ovarian carcinoma: current status and future directions. Semin Oncol. 2009;36:112–125
- A phase III study of Doxil/Caelyx versus paclitaxel in platinum-treated, taxane-naive relapsed ovarian cancer. Proc Am Soc Clin Oncol. 2002;21:[abstr 808]
- . Long-term survival advantage for women treated with pegylated liposomal doxorubicin compared with topotecan in a phase 3 randomized study of recurrent and refractory epithelial ovarian cancer. Gynecol Oncol. 2004;95:1–8
- Paclitaxel plus platinum-based chemotherapy versus conventional platinum-based chemotherapy in women with relapsed ovarian cancer: the ICON4/AGO-OVAR-2.2 trial. Lancet. 2003;361:2099–2106
- Gemcitabine plus carboplatin compared with carboplatin in patients with platinum-sensitive recurrent ovarian cancer: an intergroup trial of the AGO-OVAR, the NCIC CTG, and the EORTC GCG. J Clin Oncol. 2006;24:4699–4707
- . GLOBO-CAN 2002: cancer incidence, mortality and prevalence worldwide. IARC Cancer Base 2004; 5 version. Lyon: IARC Press; 2004;
- . Optimizing treatment for cervical cancer: the value of chemoradiation. Am J Cancer. 2004;3:215–227(13)
- . Neoadjuvant chemotherapy for locally advanced cervix cancer: a systematic review and meta-analysis of individual patient data from 21 randomized controlled trials. Eur J Cancer. 2003;39:2470–2486
- Concomitant radiochemotherapy plus surgery in locally advanced cervical cancer: update of clinical outcome and cyclooxygenase-2 as predictor of treatment susceptibility. Oncology. 2004;67:103–111
- . Chemotherapy for cervical carcinoma: factors determining response and implications for clinical trial design. J Clin Oncol. 1998;16:1879–1884
- Activity of topotecan, a new topoisomerase I inhibitor, against human tumor colony-forming units in vitro. J Natl Cancer Inst. 1992;84:1816–1820
- . Topoisomerase I inhibitors. An overview of the camptothecin analogs. Hematol Oncol Clin North Am. 1994;8:333–355
- Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors. Cancer Chemother Pharmacol. 1995;36:393–403
- Up-front window trial of topotecan in previously untreated children and adolescents with metastatic rhabdomyosarcoma: an intergroup rhabdomyosarcoma study. J Clin Oncol. 2001;19:213–219
- . The current status of camptothecin analogues as antitumor agents. J Natl Cancer Inst. 1993;85:271–291
- . Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies. Cancer Chemother Rep. 1972;56:515–521
- . Camptothecin analogues: studies from the Johns Hopkins Oncology Center. Cancer Chemother Pharmacol. 1994;34(Suppl.):S53–S57
- The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J Am Chem Soc. 1966;88:3888–3890
- . Preliminary pharmacologic and clinical evaluation of camptothecin sodium (NSC-100880). Cancer Chemother Rep. 1970;54:461–470
- . Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer. Cancer Chemother Rep. 1972;56:95–101
- Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II. Cancer Res. 1988;48:3537–3543
- Lorusso D, Mainenti S, Scambia G. Ruolo di topotecan in Ginecologia Oncologica. Pacini Editore; 2008.
- . Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin. Mol Pharmacol. 1988;34:755–760
- . Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem. 1985;260:14873–14878
- . Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin. Cancer Res. 1989;49:5077–5082
- . Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin. Cancer Res. 1988;48:1722–1726
- . Structure–activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity. Cancer Res. 1989;49:1465–1469
- Aphidicolin protects non S-phase human colon carcinoma HT-29 cells against killing by camptothecin. Proc AACR. 1991;32:336
- . Clinical status and optimal use of topotecan. Oncology (Williston Park). 1997;11:1635–1646[discussion 49–51, 55–57]
- . DNA topoisomerases. Enzymes that catalyze the concerted breaking and rejoining of DNA bonds. In: Tayler JH editors. Molecular genetics, Part III. Academic Press; 1979;p. 65–88
- . Interaction between DNA and an Escherichia coli protein omega. J Mol Biol. 1971;55:523–533
- . Recent studies of DNA topoisomerases. Biochim Biophys Acta. 1987;909:1–9
- . Plant antitumor agents. 25. Total synthesis and antileukemic activity of ring A substituted camptothecin analogues. Structure–activity correlations. J Med Chem. 1987;30:1774–1779
- . Plant antitumor agents. 28. Resolution of a key tricyclic synthon, 5′(RS)-1,5-dioxo-5′-ethyl-5′-hydroxy-2′H,5′H,6′H-6′-oxopyrano[3′,4′- f]delta 6,8-tetrahydro-indolizine: total synthesis and antitumor activity of 20(S)- and 20(R)-camptothecin. J Med Chem. 1987;30:2317–2319
- . A model for tumor cell killing by topoisomerase poisons. Cancer Cells. 1990;2:23–27
- . DNA topoisomerase poisons as antitumor drugs. Annu Rev Biochem. 1989;58:351–375
- . The reconstitution of higher-order DNA structure after X-irradiation of mammalian cells. Biochem Biophys Res Commun. 1983;112:1077–1084
- . Elevated topoisomerase II activity and altered chromatin in nitrogen mustard-resistant human cells. NCI Monogr. 1987;95–98
- . DNA topoisomerase-trapping antitumour drugs. Eur J Cancer. 1992;28A:2055–2060
- . Effects of camptothecin on the breakage and repair of DNA during the cell cycle. Cancer Res. 1973;33:2834–2836
- Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity. J Med Chem. 1991;34:98–107
- . A phase I study of topotecan as a radiosensitizer for brainstem glioma of childhood: first report of the Children's Cancer Group-0952. Neuro Oncol. 2003;5:8–13
- . The S-phase cytotoxicity of camptothecin. Exp Cell Res. 1991;193:27–35
- . The pharmacokinetics of topotecan and its carboxylate form following separate intravenous administration to the dog. Pharm Res. 1997;14:1461–1465
- . Clinical pharmacokinetics of topotecan. Clin Pharmacokinet. 1996;31:85–102
- Response to topotecan of symptomatic brain metastases of small-cell lung cancer also after whole-brain irradiation. a multicentre phase II study. Eur J Cancer. 2002;38:1724–1729
- A phase I clinical and pharmacokinetic study of the topoisomerase I inhibitor topotecan (SK&F 104864) given as an intravenous bolus every 21 days. Anticancer Drugs. 1992;3:337–345
- . The role of topotecan in treating small cell lung cancer: second-line treatment. Lung Cancer. 2003;41(Suppl. 4):S3–8
- A randomised trial of oral versus intravenous topotecan in patients with relapsed epithelial ovarian cancer. Eur J Cancer. 2002;38:57–63
- Data on file. SmithKline Beecham Pharmaceuticals; 1999.
- . Plasma and cerebrospinal fluid pharmacokinetic study of topotecan in nonhuman primates. Cancer Res. 1993;53:725–727
- Topotecan—a new treatment option in the therapy of brain metastases of lung cancer. Front Radiat Ther Oncol. 1999;33:354–363
- Pharmacokinetics and pharmacodynamics of topotecan given on a daily-times-five schedule in phase II clinical trials using a limited-sampling procedure. Cancer Chemother Pharmacol. 1996;38:254–260
- . Improved therapeutic index of lower dose topotecan chemotherapy in recurrent ovarian cancer. Gynecol Oncol. 2001;83:257–262
- Efficacy of a toxicity-adjusted topotecan therapy in recurrent small cell lung cancer. Eur Respir J. 2006;27(6):1183–1189
- . Topotecan dosing guidelines in ovarian cancer: reduction and management of hematologic toxicity. Oncologist. 2004;9:33–42
- Topotecan in second-line therapy of SCLC: impact on survival?. Onkologie. 2000;23(Suppl. 3):9–12
- Population pharmacokinetic and adverse event analysis of topotecan in patients with solid tumors. Clin Pharmacol Ther. 2002;71:334–348
- . Topotecan (Hycamtin) in the therapy of recurrent ovarian carcinoma. Onkologie. 1998;21(Suppl. 4):2–5
- Topotecan: tolerability, response rate and survival associated with extended therapy in relapsed ovarian cancer—results of a pooled analysis of 523 patients. Eur J Oncol. 1999;35(Suppl. 4):
- . Gewebetoxizitat und Paravasatbehandlung neuer Zytostatika (Soft tissue toxicity and treatment of extravasation of new cytostatics). Krankenhauspharmazie. 1996;17:471–473
- Extravasation of topotecan: a report of two cases. J Oncol Pharmacy Pract. 1997;3:115–116
- . Prolonged oral etoposide as second-line therapy for platinum-resistant and platinum-sensitive ovarian carcinoma: a Gynecologic Oncology Group study. J Clin Oncol. 1998;16:405–410
- Phase II study of vinorelbine in patients with pretreated advanced ovarian cancer: activity in platinum-resistant disease. J Clin Oncol. 1996;14:2546–2551
- Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian cancer. J Clin Oncol. 1997;15:2183–2193
- Topotecan compared with no therapy after response to surgery and carboplatin/paclitaxel in patients with ovarian cancer: Multicenter Italian Trials in Ovarian Cancer (MITO-1) randomized study. J Clin Oncol. 2004;22:2635–2642
- . Update on the role of topotecan in the treatment of recurrent ovarian cancer. Oncologist. 2002;7(Suppl. 5):3–10
- . Recurrent epithelial ovarian carcinoma: a randomized phase III study of pegylated liposomal doxorubicin versus topotecan. J Clin Oncol. 2001;19:3312–3322
- A phase II clinical trial of topotecan and carboplatin in patients with newly diagnosed advanced epithelial ovarian cancer. Int J Gynecol Cancer. 2007;17:367–372
- Prolonged topotecan infusion with cisplatin in the first-line treatment of ovarian cancer: an NYGOG and ECOG study. Gynecol Oncol. 2006;100:324–329
- . A phase II study of sequential carboplatin, paclitaxel and topotecan in patients with previously untreated advanced ovarian cancer. Br J Cancer. 2004;90:810–814
- Randomized phase III trial of topotecan following carboplatin and paclitaxel in first-line treatment of advanced ovarian cancer: a gynecologic cancer intergroup trial of the AGO-OVAR and GINECO. J Natl Cancer Inst. 2006;98:1036–1045
- Evaluation of new platinum-based treatment regimens in advanced-stage ovarian cancer: a Phase III Trial of the Gynecologic Cancer Intergroup. J Clin Oncol. 2009;27:1419–1425
- . Clinical guidelines for managing topotecan-related hematologic toxicity. Oncologist. 1998;3:4–10
- . Profound thrombocytopenia in previously treated patients with recurrent ovarian carcinoma receiving topotecan. Gynecol Oncol. 1998;69:175–178
- . Phase 2 evaluation of topotecan administered on a 3-day schedule in the treatment of platinum- and paclitaxel-refractory ovarian cancer. Gynecol Oncol. 2000;79:116–119
- Efficacy and toxicity of weekly topotecan in recurrent epithelial ovarian and primary peritoneal cancer. Gynecol Oncol. 2007;105:205–210
- . Weekly topotecan for recurrent platinum resistant ovarian cancer. Gynecol Oncol. 2008;108:53–57
- Phase II study of intravenous topotecan as a 5-day infusion for refractory epithelial ovarian carcinoma. J Clin Oncol. 1996;14:1552–1557
- Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer. N Engl J Med. 1996;334:1–6
- . Topotecan in platinum- and paclitaxel-resistant ovarian cancer. Gynecol Oncol. 1997;66:480–486
- . Current role and future aspects of topotecan in relapsed ovarian cancer. Curr Med Res Opin. 2009;25:639–651
- Oral topotecan as single-agent second-line chemotherapy in patients with advanced ovarian cancer. J Clin Oncol. 2001;19:3967–3975
- . A phase I/II trial of weekly topotecan and carboplatin in potentially platinum-sensitive relapsed ovarian and peritoneal carcinoma. Gynecol Oncol. 2005;99:714–719
- Topotecan and carboplatin in patients with platinum-sensitive recurrent ovarian cancer. Results of a multicenter NOGGO: phase I/II study. Cancer Chemother Pharmacol. 2008;62:393–400
- A phase I/II study of topotecan in combination with carboplatin in recurrent epithelial ovarian cancer. Gynecol Oncol. 2001;83:477–480
- . The platinum compounds and paclitaxel in the management of carcinomas of the endometrium and uterine cervix. Semin Oncol. 1995;22:67–75
- . Topotecan in the management of cervical cancer. Expert Opin Pharmacother. 2007;8:227–236
- . Sensitivity to topoisomerase I inhibitors and cisplatin is associated with epidermal growth factor receptor expression in human cervical squamous carcinoma ME180 sublines. Cancer Chemother Pharmacol. 2001;47:473–480
- . Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: a rational approach to clinical protocol design. J Natl Cancer Inst. 1994;86:1517–1524
- . In vitro and in vivo interaction between cisplatin and topotecan in ovarian carcinoma systems. Cancer Chemother Pharmacol. 1998;41:385–390
- Randomized phase III trial of cisplatin with or without topotecan in carcinoma of the uterine cervix: a Gynecologic Oncology Group Study. J Clin Oncol. 2005;23:4626–4633
- Randomized trial of neoadjuvant chemotherapy comparing paclitaxel, ifosfamide, and cisplatin with ifosfamide and cisplatin followed by radical surgery in patients with locally advanced squamous cell cervical carcinoma: the SNAP01 (Studio Neo-Adjuvante Portio) Italian Collaborative Study. J Clin Oncol. 2005;23:4137–4145
- Weekly topotecan and cisplatin (TOPOCIS) as neoajuvant chemotherapy for locally-advanced squamous cervical carcinoma: results of a phase II study. Proc Am Soc Clin Oncol:. 2008;[abstr 16500]
- Topotecan has substantial antitumor activity as first-line salvage therapy in platinum-sensitive epithelial ovarian carcinoma: a Gynecologic Oncology Group study. J Clin Oncol. 2000;18:1062–1067
PII: S1040-8428(09)00158-9
doi: 10.1016/j.critrevonc.2009.08.001
© 2009 Elsevier Ireland Ltd. All rights reserved.
« Previous
Next »
Critical Reviews in Oncology / Hematology
Volume 74, Issue 3
, Pages 163-174
, June 2010
