Critical Reviews in Oncology / Hematology
Volume 74, Issue 3 , Pages 211-217 , June 2010

Adjuvant chemotherapy in elderly patients with colorectal cancer. A retrospective analysis of the implementation of tumor board recommendations in a single institution

  • Jean-Emmanuel Kurtz

      Affiliations

    • Pôle d’Hématologie et d’Oncologie, Hôpitaux Universitaires de Strasbourg, 1 Avenue Molière, 67098 Strasbourg, France
    • Corresponding Author InformationCorresponding author. Tel.: +33 3 88 12 84 36; fax: +33 3 88 12 76 81.
    • ,
  • Damien Heitz

      Affiliations

    • Unité Pilote d’Oncogériatrie, Hôpitaux Universitaires de Strasbourg and Centre Paul Strauss, Strasbourg, France
    • ,
  • Sebastian Serra

      Affiliations

    • Pôle d’Hématologie et d’Oncologie, Hôpitaux Universitaires de Strasbourg, 1 Avenue Molière, 67098 Strasbourg, France
    • ,
  • Cécile Brigand

      Affiliations

    • Pôle pathologies digestives, hépatiques et de la transplantation, Hôpitaux Universitaires de Strasbourg, France
    • ,
  • Vanessa Juif

      Affiliations

    • Pôle pathologies digestives, hépatiques et de la transplantation, Hôpitaux Universitaires de Strasbourg, France
    • ,
  • Valérie Podelski

      Affiliations

    • Pôle Hépato-Digestif, Hôpitaux Universitaires de Strasbourg, France
    • ,
  • Pierre Meyer

      Affiliations

    • Département de biostatistiques, Université de Strasbourg, France
    • ,
  • Valère Litique

      Affiliations

    • Pôle d’Hématologie et d’Oncologie, Hôpitaux Universitaires de Strasbourg, 1 Avenue Molière, 67098 Strasbourg, France
    • ,
  • Jean-Pierre Bergerat

      Affiliations

    • Pôle d’Hématologie et d’Oncologie, Hôpitaux Universitaires de Strasbourg, 1 Avenue Molière, 67098 Strasbourg, France
    • ,
  • Serge Rohr

      Affiliations

    • Pôle pathologies digestives, hépatiques et de la transplantation, Hôpitaux Universitaires de Strasbourg, France
    • ,
  • Patrick Dufour

      Affiliations

    • Centre Paul Strauss, Strasbourg, France

,Accepted 29 May 2009.

References 

  1. Ciccolallo L, Capocaccia R, Coleman MP, et al. Survival differences between European and US patients with colorectal cancer: role of stage at diagnosis and surgery. Gut. 2005;54:268–273
  2. Martijn H, Voogd AC, van de Poll-Franse LV, et al. Improved survival of patients with rectal cancer since 1980: a population-based study. Eur J Cancer. 2003;39:2073–2079
  3. Kurtz JE, Andrès E, Natarajan-Amé S, Noel E, Dufour P. Oral chemotherapy in colorectal cancer treatment: review of the literature. Eur J Intern Med. 2003;14:18–25
  4. Sargent D, Sobrero A, Grothey A, et al. Evidence for cure by adjuvant therapy in colon cancer: observations based on individual patient data from 20,898 patients on 18 randomized trials. J Clin Oncol. 2009;27:872–877
  5. Monnet E, Faivre J, Raymond L, Garau I. Influence of stage at diagnosis on survival differences for rectal cancer in three European populations. Br J Cancer. 1999;81:463–468
  6. Aparicio T, Navazesh A, Boutron I, et al. Half of elderly patients routinely treated for colorectal cancer receive a sub-standard treatment. Crit Rev Oncol Hematol. 2009;[Epub ahead of print]
  7. Schrag D, Cramer LD, Bach PB, Begg CB. Age and adjuvant chemotherapy use after surgery for stage III colon cancer. J Natl Cancer Inst. 2001;93:850–857
  8. Rougier P, Mitry E, Aranda E, Daniele B, Labianca R, Carrato A. Elderly colorectal cancer patients are undertreated. Eur J Cancer. 2004;2:8–13
  9. Sargent DJ, Goldberg RM, Jacobson SD, et al. A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med. 2001;345:1091–1097
  10. Van Cutsem EDJ, Oliveira J. Colon cancer: ESMO clinical recommendations for diagnosis, adjuvant treatment and follow-up. Ann Oncol. 2008;19(Suppl. 2):ii29–ii30
  11. Bouvier AM. Epidémiologie descriptive du cancer colorectal en France. http://www.invs.sante.fr/beh/2009/02_03/beh_02_03_2009.pdf. Accessed April 3, 2009.
  12. Golfinopoulos V, Pentheroudakis G, Pavlidis N. Treatment of colorectal cancer in the elderly: a review of the literature. Cancer Treat Rev. 2006;32:1–8
  13. André T, Boni C, Mounedji-Boudiaf L, et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med. 2004;350:2343–2351
  14. Zeber JE, Copeland LA, Hosek BJ, Karnad AB, Lawrence VA, Sanchez-Reilly SE. Cancer rates, medical comorbidities, and treatment modalities in the oldest patients. Crit Rev Oncol Hematol. 2008;67:237–242
  15. Kurtz JE, Heitz D, Enderlin P, et al. Geriatric oncology, general practitioners and specialists. Current opinions and unmet needs. Crit Rev Oncol Hematol. 2009;
  16. Neugut AI, Matasar M, Wang X, et al. Duration of adjuvant chemotherapy for colon cancer and survival among the elderly. J Clin Oncol. 2006;24:2368–2375
  17. Scheithauer W, McKendrick J, Begbie S, et al. Oral capecitabine as an alternative to i.v. 5-fluorouracil-based adjuvant therapy for colon cancer: safety results of a randomized, phase III trial. Ann Oncol. 2003;14:1735–1743
  18. Papamichael D, Audisio R, Horiot JC, et al. Treatment of the elderly colorectal cancer patients: SIOG expert recommendations. Ann Oncol. 2009;20:5–16
  19. Gross CP, MacAvay GJ, Guo Z, Tinetti ME. The impact of chronic illness on the uses and effectiveness of adjuvant chemotherapy for colon cancer. Cancer. 2007;109:2410–2419

PII: S1040-8428(09)00120-6

doi: 10.1016/j.critrevonc.2009.05.003

Critical Reviews in Oncology / Hematology
Volume 74, Issue 3 , Pages 211-217 , June 2010

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