Critical Reviews in Oncology / Hematology
Volume 74, Issue 3 , Pages 149-155, June 2010

MicroRNA and leukemia: Tiny molecule, great function

  • Haifeng Zhao

      Affiliations

    • State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, PR China
    • ,
  • Donghai Wang

      Affiliations

    • Albert Einstein Cancer Center/Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA
    • ,
  • Weiting Du

      Affiliations

    • State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, PR China
    • ,
  • Dongsheng Gu

      Affiliations

    • State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, PR China
    • ,
  • Renchi Yang

      Affiliations

    • State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, PR China
    • Corresponding Author InformationCorresponding author. Tel.: +86 22 23909122; fax: +86 22 23909047.

Accepted 14 May 2009. published online 11 June 2009.

Abstract 

MicroRNAs are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their targeted messenger RNAs (mRNAs). It is known that aberrant microRNA expression can play a vital role in the pathology of leukemia, thus microRNAs have rapidly emerged as potential targets for therapeutics. This review focuses on recent researches on the important roles of microRNAs in the pathogenesis of leukemia, including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML) and chronic lymphocytic leukemia (CLL).

Keywords: MicroRNA, Acute myeloid leukemia, Acute lymphoblastic leukemia, Chronic myeloid leukemia, Chronic lymphocytic leukemia

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PII: S1040-8428(09)00103-6

doi:10.1016/j.critrevonc.2009.05.001

Critical Reviews in Oncology / Hematology
Volume 74, Issue 3 , Pages 149-155, June 2010

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